Casodex ,90 mg, 90 tablets

€336.00
Dimensions (sm): 0.00 x 0.00 x 0.00
Weight (sm): 0.00

The drug is a medicine that suppresses the effects of male sex hormone (testosterone) (non-steroidal antiandrogen).

Used to treat locally advanced prostate cancer and a high risk of disease progression.

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Contraindications

Hypersensitivity to the components of the drug, the simultaneous administration of terfenadine, astemizole and cisapride, children's age, pregnancy, lactation.

With caution. Liver failure.

Dosage and administration

For advanced prostate cancer, by mouth, 50 mg Casodex / day once in combination with an analogue of LHF or surgical castration.

With non-metastatic prostate cancer in situ as monotherapy (if there are contraindications for surgical castration or for the appointment of other drugs) - 150 mg / day once.

Casodex should be taken continuously for at least 2 years.

In patients with moderate to severe impaired liver function, a dose adjustment is required.

pharmachologic effect

An antitumor agent, a non-steroidal antiandrogen drug, is a competitive antagonist of endogenous androgens. By binding to receptors on the surface of the cells of target organs, it makes them inaccessible to androgens, while increasing the concentration of hormones in the plasma. The result of this is a regression of neoplasms of the prostate gland.

Administration of Casodex in a dose of 150 mg / day to patients with localized (T1-T2, N0 or NX, M0) or locally advanced (T3-T4, any N, M0; T1-T2, N +, M0) prostate cancer reduces the risk of disease progression by 42% and the relative risk of bone metastasis by 33% during the observation period up to 2 years.

In some patients, cessation of admission can lead to the development of a syndrome of "cancellation" of antiandrogens (after cancellation, 10-15% of patients have a temporary stabilization of the disease).

Side effects

From the CCC: angina pectoris, development or aggravation of heart failure, increased blood pressure.

From the respiratory system: chest pain, cough, pharyngitis, bronchitis, pneumonia, rhinitis.

From the nervous system: dizziness, insomnia or drowsiness, anxiety.

From the musculoskeletal system: myasthenia gravis, myalgia, cramps, arthritis, joint contractures.

From the endocrine system: gynecomastia (may persist after discontinuation of therapy, especially in the case of taking the drug for a long time), soreness of the mammary glands; hyperglycemia, diabetes mellitus, polyuria.

From the urinary system: dysuria, urinary retention, edema, rarely - hematuria.

Other: asthenia, alopecia, weight loss or increase, decreased libido; fever, chills, sweating, anemia, pelvic pain, dry skin, hirsutism, allergic reactions, flushing of the face.

Overdose

Treatment: symptomatic, specific antidote does not exist. Dialysis is ineffective, because Casodex is firmly bound to proteins and is not excreted unchanged in urine. General supportive therapy and monitoring of vital body functions are recommended.

special instructions

During treatment with Casodex, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Interaction

Enhances the effects of indirect anticoagulants.

Increases AUC of midazolam by 80%.

The use of Casodex is incompatible with terfenadine, astemizole, cisapride.

Increases the risk of adverse effects when given concomitantly with cyclosporine, BMCC, drugs that inhibit microsomal oxidation of drugs (including cimetidine, ketoconazole).

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