Drytec ,2,5 - 100 GBq 7,5 GBq x 1

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What is it and what is it used for?

DRYTEC is a nuclear medical diagnostic (ATC V09F X01) for intravenous administration (after elution and, if necessary, a radioactive label).

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Eluate (sodium pertechnetate solution [99mTc] for injection, Ph. Eur.) From a radionuclide generator can be used

for the radioactive labeling of a radioactive drug kit that has been specifically developed and approved for the radioactive labeling of sodium pertechnetate (99mTc).

With direct intravenous administration, a sterile solution of sodium pertechnetate [99mTc] for injection is used for diagnostic purposes in the following cases:

Thyroid scintigraphy: direct display and measurement of thyroid absorption in order to obtain information about the size, location and function of the gland and the presence of nodules in thyroid diseases

Salivary gland scintigraphy: the diagnosis of chronic sialadenitis (e.g., Sjogren's syndrome), as well as monitoring the function of the salivary glands in salivary gland diseases and therapeutic interventions (especially radioiodine therapy).

Localization of the ectopic gastric mucosa (Meckel diverticulum).

Brain scintigraphy: to detect blood-brain barrier disorders due to tumors or metastases in case of unclear results of CT or MRI and to diagnose brain death.

After sterile sodium pertechnetate [99mTc] is introduced into the Rickham tank

Shunting scintigraphy: check the patency of ventricular shunts with hydrocephalus.

After instilling a sterile solution of sodium pertechnetate [99mTc] in the eye:

Scintigraphy of the lacrimal ducts: to elucidate functional disorders of the lacrimal flow, to monitor the course and evaluate success after therapeutic measures.

DRYTEC should not be used,

if - you have hypersensitivity (allergy) to sodium pertechnetate (99mTc) or any other DRYTEC component.

For information on contraindications for use in the radioactive labeling of a radioactive drug kit, see Technical Information and Instructions for Using the Radioactive Drug Kit.

When using DRYTEC, special care must be taken, therefore

Radioactive medicines may be taken, processed and used only by authorized persons in specially designated clinical areas. Its handling and use are governed by the rules of the local supervisory authority and / or relevant permits.

When examining the thyroid gland, salivary glands and ducts (Meckel) in the small intestine (Meckel diverticulum), the simultaneous use of sodium perchlorate can lead to a significant decrease in the absorption of radioactivity by glandular tissue. In brain scintigraphy, sodium pertechnetate (99mTc) is also found in the choroid plexus, which may be misinterpreted as a violation of the blood-brain barrier (false-positive result). To avoid such false results and reduce radiation exposure, pre-treatment with perchlorate is recommended because perchlorate also blocks the absorption of sodium pertechnetate (99mTc) into the vascular plexus. A thyroid block to reduce radiation exposure is also required before shunt scintigraphy.

After in vivo labeling of red blood cells with tin as a reducing agent, sodium pertechnetate (99mTc) is mainly incorporated into red blood cells; therefore, Meckel scintigraphy should be carried out before or several days after scintigraphy in a blood pool with in vivo labeled red blood cells.

With salivary gland scintigraphy, a lower specificity of the method is expected compared to MR sialography.

In children and adolescents, a particularly cautious compromise is needed between the expected diagnostic information and the risk associated with exposure. Thyroid blocking as part of a brain scan is especially important for children.

Avoid paravascular injection.

To reduce bladder irradiation, the patient's water balance should be balanced during the examination, and the patient should be asked to drink enough after the examination and often empty the bladder.

In patients with impaired renal function, strict guidance is required, as these patients may experience increased exposure.

For information on warnings and precautions when using a radioactive drug kit for labeling, please refer to the technical information and information on using the appropriate radioactive drug kit.

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