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Secukinumab (cosentix) is a fully human antibody (immunoglobulin G1 (IgGl) that selectively binds and neutralizes the pro-inflammatory cytokine interleukin-17A (IL-17A). Secukinumab has a targeted effect on IL-17 and inhibition of its interaction with the IL-17 receptor , which is expressed by different types of cells, including keratinocytes and synoviocytes.